Looking Through the Vascular Normalization Window: Timing Antiangiogenic Treatment and Chemotherapy with 99mTc-Annexin A5
نویسندگان
چکیده
منابع مشابه
Development and Evaluation of a Novel 99mTc-Labeled Annexin A5 for Early Detection of Response to Chemotherapy
(99m)Tc-HYNIC-annexin A5 can be considered as a benchmark in the field of apoptosis imaging. However, (99m)Tc-HYNIC-annexin A5 has characteristics of high uptake and long retention in non-target tissues such as kidney and liver. To minimize this problem, we developed a novel (99m)Tc-labeled annexin A5 using a bis(hydroxamamide) derivative [C3(BHam)2] as a bifunctional chelating agent, and evalu...
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Tc-HYNIC-annexin A5 can be considered as a benchmark in the field of apoptosis imaging. However, Tc-HYNICannexin A5 has characteristics of high uptake and long retention in non-target tissues such as kidney and liver. To minimize this problem, we developed a novel Tc-labeled annexin A5 using a bis(hydroxamamide) derivative [C3(BHam)2] as a bifunctional chelating agent, and evaluated its usefuln...
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UNLABELLED Apoptosis, or programmed cell death (PCD), contributes to the decline in ventricular function in heart failure. Because apoptosis comprises a programmed cascade of events, it is potentially reversible, and timely intervention should delay the development of cardiomyopathy. (99m)Tc-Labeled annexin A5 has successfully been used for the noninvasive detection of PCD in myocardial infarct...
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To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure IFP in tumor tissue domain decreases while the pressure gradient increases during the normalizatio...
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Editorial Malaria is a potentially life-threatening disease with 200–500 million new infections and up to one million deaths annually. 1 Half the world's population is at risk of being infected by one of the five Plasmodium parasite species causing malaria in humans. P. falciparum is responsible for the most fatal outcomes occurring in sub-Saharan Africa. 2 Infection can progress very fast from...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2011
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.111.097725